International Journal of Humanities, Engineering and pharmaceutical science | IJHEPS | International Pharma Journal | Callofpaper IJHEPS

e-ISSN 2320-2955, p-ISSN 2249-2569, ISBN 978-81-909047-9-7

INTERNATIONAL RESEARCH JOURNAL OF HUMANITIES,
ENGINEERING & PHARMACEUTICAL SCIENCES

(An International Registered Research Journal)

IJHEPS NEW




PHARMACY
Title SYNERGISTIC HEPATOCARDIOPROTECTIVE AND ANTIOXIDANT EFFECTS OF MYRRH AND ASCORBIC ACID AGAINST DIAZINON-INDUCED TOXICITY ON RABBITS
Authors

Mohamed M. Abdel-Daim* & Safaa M. Halawa

Page No 1-7
Code Int./JAN14/PH655
Affiliation

Suez Canal University, Ismailia, Egypt

Abstract

Diazinon (DZN) is a widely used organophosphrus synthetic and acaricide widely used for agricultural and veterinary purposes. However, its human and animal exposure leads to hepatocardiotoxicity. Our experimental objective was to evaluate protective effects of Myrrh; Commiphora molmol or/ and ascorbic acid; vitamin C against DZN-induced hepatocardiotoxicity in healthy male white New Zealand rabbits (Oryctolagus cuniculus). DZN-treated animals revealed significant alterations in serum biochemical parameters related to hepatic and cardiac injuries. There was a significant increase in hepatic and cardiac lipid peroxidation and significant inhibition in tissue antioxidant biomarkers due to DZN intoxication. Both myrrh and vitamin C protect against DZN-induced serum as well as hepatic and cardiac tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both myrrh and vitamin C produced synergetic hepatocardioprotective and antioxidant effects. Therefore, it could be concluded that myrrh and/or vitamin C administration able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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