INTERNATIONAL RESEARCH JOURNAL OF HUMANITIES,
ENGINEERING & PHARMACEUTICAL SCIENCES

Swati Tiwari and Neetesh Kumar Jain

Oriental University, Indore

The aim of the present study was to investigate the effect of hepatoprotective activity of aqueous extract of triphala loaded solid lipid nanoparticle in isoniazid-rifampicin induced hepatotoxicity in rats. Wistar Albino rats of either sex weighing between (200-250 gm) were selected and treated for 21 days which were further divided into various groups including Toxic, standard and treatment groups respectively. The biochemical markers like (AST, ALT, ALP and serum bilirubin) were estimated by using Erba diagnostic kit. The in vivo antioxidant activity was determined by estimating the tissue levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO). Histopathology of liver was also carried out. The triphala/ bioactive & their formulation (100 and 50mg/kg) produced significant effect by decreasing the activity or level of AST, ALT, ALP and serum bilirubin and while it significantly increased the levels of tissue GSH, SOD and CAT in a dose-dependent manner. From the present study it can be concluded that aqueous extract of triphala/bioactive & their formulation possesses hepatoprotective activity against isoniazid-rifampicin induced hepatotoxicity.