INTERNATIONAL RESEARCH JOURNAL OF HUMANITIES,
ENGINEERING & PHARMACEUTICAL SCIENCES

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. The solubility of drugs molecules remains one of the most challenging aspects in formulation development. With the advent of combinatorial chemistry and high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. So many times it becomes challenging to formulate poorly water soluble drugs. Therefore it is necessary to improve solubility of drug by some methods like co-solvency, salt formation, addition of solubilizing agent, Micronization, Complexation, solid dispersion. Although these techniques have commonly been used to increase dissolution rate of the drug. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.