INTERNATIONAL RESEARCH JOURNAL OF HUMANITIES,
ENGINEERING & PHARMACEUTICAL SCIENCES

The proposed research program is continuation of the research work, which has been carried out on the synthesis and biological studies of some isatin (indole 2,3-diones). In this connection fifty-seven derivatives were prepared. The substitution was made at position such as 1 and 3. The isatin derivatives (MP VA-F) were prepared by the substituted of different aldehydes by reacting the mixture of (3Z)-3-[(4-hydrazinylphenyl)imino]-1,3-dihydro-2H-indol-2-one with the presence of with glacial acetic acid. Isatin derivatives with acid anhydride were prepared and isatin derivatives were also reacted with isatin having 85% yield. All these new compounds have been screened for their antimicrobial activity against test organism.