INTERNATIONAL RESEARCH JOURNAL OF HUMANITIES,
ENGINEERING & PHARMACEUTICAL SCIENCES

Background and Objectives Peptic ulcer is a common gastrointestinal disease and it affects particularly the working years of a patient’s life and its social implications are considerable. In the indigenous system of medicine, the DM bark is reported to be useful in the treatment of gastric ulceration. Hence, in the present study, the DM bark has been selected for its anti-ulcer potency on experimentally induced ulcer in rats. Materials and Methods The authenticated DM bark, were dried in shade and powdered coarsely. Extraction was done according to standard procedure using analytical grade solvents. The coarse powder of DM bark was Soxlet extracted with the solvents with increasing order of polarity i.e. petroleum ether (60-80oc), chloroform (59.5-61.5oc), ethanol (64.5-65.5oc), and distilled water. The extracts obtained were concentrated under reduced pressure. In the pharmacological screening, the effect of different extracts of DM bark was evaluated for their anti-ulcer profile by using Pylorus ligation, aspirin and ethanolic induced models using albino rats. Results and Discussion Preliminary phytochemical investigation revealed the presence of carbohydrates, proteins, steroids, tannins and glycosides in aqueous and ethanolic extracts. LD50 cut-off dose was found to be 2000 mg/kg b.w. for the extracts of DM bark. Hence therapeutic dose was taken as 500 mg/kg b.w. for all extracts. Treatment with Aqueous and ethanolic extract of DM bark significantly showed the anti-ulcer activity as compared to control. The histopathological study of the stomach also supported the above results. The results were comparable to that of standard drug (Lansoprazole)