|Title||COCRYSTAL FORMATION: A REVIEW|
Dr. Mohd Sohrab
Azad Institute of Pharmacy
There are two ways of producing cocrystals; they are solution based and grinding methods. The solution based method is important one because of its nature of producing most of the cocrystals which can qualify for the single X-ray diffraction (SXRD) testing. It includes evaporation of a heterometric solution method, reaction crystallisation and cooling crystallization methods. Whereas grinding methods include neat grinding and solvent drop grinding. Apart from these convictional methods of co-crystallization methods, today there are many other new emerging methods, such as cocrystallisation using supercritical fluid, hot-stage microscopy, and ultrasound assisted.