|Title||SIMULTANEOUS SPECTROPHTOMERIC ESTIMATION OF OLANZAPINE AND FLUOXETINE IN SOLID DOSAGE FORM|
Trupti Lokhande & Sandip kamble
RCP & S.S Medical College, Rewa
Olanzapine and Fluoxetine are used as antipsychotics which are available in tablet dosage form in the ratio of 1:4. Two simple and accurate procedures for simultaneous estimation of Olanzapine and Fluoxetine in tablet formulation have been developed. The methods employed are absorption ratio method and absorption correction method. In the absorption ratio method wavelengths selected were 235.60 nm as isobestic point and 227 nm as λmax of Fluoxetine. In absorption correction method wavelengths selected were 268.40 nm and 294 nm. Beer Lambert’s law is obeyed in the concentration range 1-10 µg mL¯¹ for Olanzapine and 4-40 µg mL¯¹ for Fluoxetine. The result of analysis has been validated by statistical and recovery studies.