|Title||CINNAMON DISSOLVED IN HONEY VERSUS OMEPRAZOLE FOR TREATMENT OF ETHANOL- INDUCED GASTRIC ULCER AND OXIDATIVE STRESS IN RATS|
Nermeen Borai El-Borai, Badr El-Said El-Bialy, Amira Shehata Abd El Latif , Enas Abd El-Aziz Tahoun
Kafr El Sheikh University, Egypt
It is well known that the drinking of alcohol leads to gastric lesions and many other deleterious effects. This study aimed to investigate the probability of using cinnamon aqueous extract (CAE) dissolved in honey versus omeprazole to counteract ethanol-induced gastric ulcer and oxidative stress in rats. Thirty five male albino rats were randomly divided into 5 groups and treated orally, 3 times weekly for 30 days. Group1, control. Group2, ethanol. Group3, honey-ethanol. Group4, CAE (200mg/kg) in honey-ethanol. Group5, omeprazole (20mg/kg)-ethanol. Ethanol caused elevation in serum ALT, AST, urea, creatinine, uric acid, glucose, cholesterol, triglycerides, HDL and VLDL levels with reduction in LDL and magnesium levels. Furthermore, Ethanol administration showed elevation of MDA contents and reduction of TAC that were only significant in stomach, liver and kidneys tissues. A significant elevation of NO content in gastric tissue was recorded. Ethanol induced oxidative damage reflected by histopathological alterations in stomach, liver, kidneys, brain and lungs. Treatment with either CAE dissolved in honey or omeprazole one hour after ethanol administration reversed all these effects and nearly returned the integrity of gastric mucosa. In conclusion, CAE dissolved in honey can be used safely versus omeprazole to reverse ethanol- induced gastric ulcer and oxidative stress.