|Title||ENHANCEMENT OF DISSOLUTION PROFILE OF ALBENDAZOLE BY SOLID DISPERSION AND FORMULATION OF TABLET USING POLOXAMER 188 AND PEG 4000|
|Authors||Rajni Sharma*, Rupa Mazumder & Archana Sharma|
|Affiliation||NIET, Noida, India|
Aim: The objective of the present study is to enhance solubility of Albendazole by preparing solid dispersion of Albendazole by melting method and formulation of tablets with the prepared solid dispersion. Method: Albendazole solid dispersion was prepared by melting technique using two polymers PEG 4000 and poloxamer 188 and then tablet was prepared by using three super disintegrants, like copovidone, crosscarmallose sodium and sodium starch glycolate in three different drug: carrier ratios and evaluated for their in vitro drug release. Result: The prepared formulations were white in colour and free flowing. The spectral data revealed that there were no drug-polymer interactions. The tablets were exposed to routine quality control tests like determination of hardness, friability, weight variation and thickness and drug content uniformity and disintegration time. The dissolution profiles of these formulations were studied in 0.1 N HCl. On the basis of in vitro dissolution results at the end of 60 min, formulation SDT6 gave the highest drug release that is 99 %.The disintegration time was found to be 44-56 seconds. The results were supported by XRD and DSC Data.